Pyrexar Medical formed to take on the fight against cancer. We purchased the Hyperthermia product line from BSD Medical in April 2015. We plan to support the existing BSD-500 and BSD-2000 customers, continue to make product improvements, support the growth of Thermal Oncology, and spread the word about this amazing cancer therapy.
Randomized clinical trials (RCT’s) have show significant improvement in clinical outcomes when hyperthermia was added to radiotherapy and/or chemotherapy. Experts in clinical hyperthermia held a consensus meeting (Kadota Fund International Forum 2004) about the evidence of the published clinical results of the RCT’s. Level 1 evidence was found for bladder cancer, breast cancer, cervical cancer, cancer of the esophagus, lymph nodes of head and neck tumors, rectum cancer, soft tissue sarcoma, malignant melanoma, glioblastoma multiform, and various superficial cancers.
According to the standards set by the Society of Thermal Medicine (STM), European Society for Hyperthermic Oncology (ESHO) and the Asian Society of Hyperthermic Oncology (ASHO), the benefits of hyperthermia are fully realized when the tumor temperature reaches 39-43 degrees Celsius.
Heat is known to kill cancer cells, shrink tumor size, increase radiosensitivity, inhibit DNA repair, oxygenate hypoxic tumors, produce heat shock proteins, and increase disease-free survival.
An independent study published in the Journal of the American Medical Association (JAMA) reports on a 10 year patient follow-up to a phase III clinical study on a Soft Tissue Sarcoma Study. In addition to higher CR, the addition of hyperthermia increased the median long-term survival rate from 6.2 to 15.4 years
In the delicate micro-environment of a cancer cell, heat can lead to direct cell death, shrinking tumor size for easier surgical resection.
Very low to no toxicity is often reported when administering hyperthermia. There is no known toxicity build-up from multiple treatments.
Increased blood flow and perfusion at the tumor site promote oxygenation, increasing radiosensitivity.
A phase III clinical study shows an increased survival benefit when hyperthermia was added to traditional therapies.
Hyperthermia, in combination with Radiotherapy, will inhibit the DNA repair cycle of radiation-damaged cancer cells.
Tumor cells express heat shock proteins when exposed to hyperthermic temperatures allowing tumor-specific antigens to reach the immune system.