BSD-2000 Published Clinical Studies

Phase I, II & III Clinical Studies that used the BSD-2000

Tumor Author Year Method No. of Patients Title Journal Abstract Link
Soft Tissue Sarcoma Lindner 2021 HT # Perioperative chemotherapy and regional hyperthermia for high-risk adult-type soft tissue sarcomas  Eur J Cancer icon 48 article
Soft Tissue Sarcoma Issels 2021 CT+HT 109 Immune infiltrates in patients with localised high-risk soft tissue sarcoma treated with neoadjuvant chemotherapy without or with regional hyperthermia: A translational research program of the EORTC 62961-ESHO 95 randomised clinical trial  Eur J Cancer icon 48 article
Soft Tissue Sarcoma Issels 2020 HT 109 Systemic antitumor effect by regional hyperthermia combined with low-dose chemotherapy and immunologic correlates in an adolescent patient with rhabdomyosarcoma – a case report  Int J Hyperthermia icon 48 article
Soft Tissue Sarcoma Bücklein 2020 ICE+HT 110 Ifosfamide, Carboplatin, and Etoposide (ICE) in Combination with Regional Hyperthermia as Salvage Therapy in Patients with Locally Advanced Nonmetastatic and Metastatic Soft-Tissue Sarcoma  Sarcoma icon 48 article
Soft Tissue Sarcoma Aklan 2019 HT # Regional deep hyperthermia: quantitative evaluation of predicted and direct measured temperature distributions in patients with high-risk extremity soft-tissue sarcoma  Int J Hyperthermia icon 48 article
Soft Tissue Sarcoma Zschaeck 2018 CT+HT 61 Neoadjuvant chemotherapy plus radiation versus chemotherapy plus regional hyperthermia in high-grade soft tissue sarcomas: a retrospective comparison  Int J Hyperthermia icon 48 article
Soft Tissue Sarcoma Issels 2018 CT vs.
CT+HT
341 Effect of Neoadjuvant Chemotherapy Plus Regional Hyperthermia on Long-term Outcomes Among Patients With Localized High-Risk Soft Tissue Sarcoma: The EORTC 62961-ESHO 95 Randomized Clinical Trial.  JAMA icon 48 article
Soft Tissue Sarcoma Eckert 2017 CT+HT 42 Radiotherapy and hyperthermia with curative intent in recurrent high risk soft tissue sarcomas   Int J Hyperthermia icon 48 article
Soft Tissue Sarcoma Angele 2014 CT vs.
CT+HT
341 Effectiveness of regional hyperthermia with chemotherapy for high-risk retroperitoneal and abdominal soft-tissue sarcoma after complete surgical resection: a subgroup analysis of a randomized phase-III multicenter study. Ann Surg Oncol icon 48 article
Soft Tissue Sarcoma Issels 2010 CT vs.
CT+HT
341 Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study. Lancet icon 48 article
Soft Tissue Sarcoma Schlemmer 2010 RCT+HT 47 Thermochemotherapy in patients with extremity high-risk soft tissue sarcomas (HR-STS) Int J Hyperthermia icon 48 article
Soft Tissue Sarcoma Fiegl 2004 CT+HT  20 Ifosfamide, carboplatin and etoposide (ICE) as second-line regimen alone and in combination with regional hyperthermia is active in chemo-pre-treated advanced soft tissue sarcoma of adults. Int J Hyperthermia icon 48 article
Soft Tissue Sarcoma Wendtner 2002 CT+HT 58 Response to neoadjuvant chemotherapy combined with regional hyperthermia predicts long-term survival for adult patients with retroperitoneal and visceral high-risk soft tissue sarcomas. JCO icon 48 article
Soft Tissue Sarcoma Issels 2001 CT+HT 59 Neoadjuvant chemotherapy combined with regional hyperthermia (RHT) for locally advanced primary or recurrent high-risk adult soft-tissue sarcomas (STS) of adults: long-term results of a phase II study. Eur J Cancer icon 48 article
Soft Tissue Sarcoma Wendtner 2001 RCT+HT 54 Treatment of primary, recurrent or inadequately resected high-risk soft-tissue sarcomas (STS) of adults: results of a phase II pilot study (RHT-95) of neoadjuvant chemotherapy combined with regional hyperthermia. Eur J Cancer icon 48 article
Soft Tissue Sarcoma Prosnitz 1999 RT+HT 97 The treatment of high-grade soft tissue sarcomas with preoperative thermoradiotherapy. IJRO icon 48 article
Soft Tissue Sarcoma Scully 1994 RT+HT 40 Clinical outcome after neoadjuvant thermoradiotherapy in high grade soft tissue sarcomas J Surg Oncol icon 48 article
Soft Tissue Sarcoma Issels 1990 CT+HT 40 Ifosfamide plus etoposide combined with regional hyperthermia in patients with locally advanced sarcomas: a phase II study. JCO icon 48 article

RT-Radiotherapy; HT-Hyperthermia; LHT-Local Hyperthermia; CHT-Chemothyperthermia; CTX-Chemotherapy; MMC-Mitomycin C; EHT; Endocavity Hyperthermia; IHT-Interstitial Hyperthermia; HIPEC-Heated Intraperitoneal Chemotherapy; RCT-RadioChemotherapy; BCG-Bacillus Calmette-Guerin; CRT-Conformal Radiotherapy