BSD-2000 Published Clinical Studies

Phase I, II & III Clinical Studies that used the BSD-2000

Tumor Author Year Method No. of Patients Title Journal Abstract Link
Rectal Ott 2021 CRT+HT 111 Neoadjuvant Chemoradiation Combined with Regional Hyperthermia in Locally Advanced or Recurrent Rectal Cancer Cancers icon 48 article
Rectal Gani 2021 RCT+HT 78 Deep regional hyperthermia with preoperative radiochemotherapy in locally advanced rectal cancer, a prospective phase II trial Radiother Oncol icon 48 article
Anal Ott 2018 CRT+HT 112 Chemoradiotherapy with and without deep regional hyperthermia for squamous cell carcinoma of the anus Strahlenther Onkol icon 48 article
Rectal Zwirner 2017 RCT+HT 86 External validation of a rectal cancer outcome prediction model with a cohort of patients treated with preoperative radiochemotherapy and deep regional hyperthermia Int J Hyperthermia icon 48 article
Rectal Gani 2016 HT 103 Long-term local control and survival after preoperative radiochemotherapy in combination with deep regional hyperthermia in locally advanced rectal cancer Int J Hyperthermia icon 48 article
Rectal Schroeder 2012 RCT vs.
RCT+HT
106 Pathological complete response and sphincter-sparing surgery after neoadjuvant radiochemotherapy with regional hyperthermia for locally advanced rectal cancer compared with radiochemotherapy alone. Int J Hyperthermia icon 48 article
Rectal Maluta 2010 RCT+HT 76 Regional hyperthermia added to intensified preoperative chemo-radiation in locally advanced adenocarcinoma of middle and lower rectum Int J Hyperthermia icon 48 article
Rectal Milani 2008 RCT+RHT 24 Radiochemotherapy in combination with regional hyperthermia in preirradiated patients with recurrent rectal cancer Strahlenther Onkol icon 48 article
Rectal Hildebrandt 2004 RT+HT 9 Regional pelvic hyperthermia as an adjunct to chemotherapy (oxaliplatin, folinic acid, 5-fluorouracil) in pre-irradiated patients with locally recurrent rectal cancer: a pilot study. Int J Hyperthermia icon 48 article
Rectal Juffermans 2003 RT+HT 54 Reirradiation and hyperthermia in rectal carcinoma: a retrospective study on palliative effect. Cancer icon 48 article
Rectal Schaffer 2003 RCT+HT 14 Feasibility and Morbidity of Combined Hyperthermia and Radiochemotherapy in Recurrent Rectal Cancer – Preliminary Results Onkologie icon 48 article
Rectal Romano 2003 RT+HT 57 Pre-operative radio-chemotherapy plus regional hyperthermia in the treatment of advanced rectal cancer: experience with radiation dose escalation IJRO icon 48 article
Rectal Anscher 2000 CT+HT 15 A pilot study of preoperative continuous infusion 5-fluorouracil, external microwave hyperthermia, and external beam radiotherapy for treatment of locally advanced, unresectable, or recurrent rectal cancer. IJRO icon 48 article
Rectal Rau 2000 RCT+HT 54 Preoperative radiochemotherapy in locally advanced or recurrent rectal cancer: regional radiofrequency hyperthermia correlates with clinical parameters. IJRO icon 48 article
Rectal Van der Zee 2000 RT vs.
RT+HT
143 Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumors: a prospective, randomized, multicentre trial. Dutch Deep Hyperthermia Group Lancet icon 48 article
Tumor Rau 1998 RCT+HT 37 Preoperative Hyperthermia Combined with Radiochemotherapy in Locally Advanced Rectal Cancer - A Phase 11 Clinical Trial Ann Surg icon 48 article