Randomized Clinical Hyperthermia Studies

The evidence is clear, Thermal Therapy Works.
In the table below you will find randomized trials over the past 30 years on the effectiveness of adding Hyperthermia to your cancer treatment protocol.

Tumor Author Year HT Technique Control Arm Exp.
Arm
No. of Patients Title Journal Abstract Link
Cervical Cancer Datta 2019 Meta-Analysis     9,894 Efficacy and Safety Evaluation of the Various Therapeutic Options in Locally Advanced Cervix Cancer: A Systematic Review and Network Meta-Analysis of Randomized Clinical Trials IJRO icon 48 article
Soft Tissue Sarcoma Issels 2018 Regional HT - BSD-2000 CT CT + HT 341 Neo-adjuvant chemotherapy alone or with regional hyperthermia for localized high-risk soft-tissue sarcoma: a randomized phase 3 multicentre study  JAMA icon 48 article
Cervical Cancer Datta 2017 Meta-Analysis     2,445 Concurrent chemoradiotherapy vs. radiotherapy alone in locally advanced cervix cancer: A systematic review and meta-analysis Gynecol Oncol  icon 48 article
Bladder Cancer Arends 2016 Intravesical Hyperthermia BCG CHT 190 Results of a Randomised Controlled Trial Comparing Intravesical Chemohyperthermia with Mitomycin C Versus Bacillus Calmette-Guerin for Adjuvant Treatment of Patients with Intermediate- and High-risk Non–Muscle-invasive Bladder Cancer  Euro Urol icon 48 article
Recurrent Breast Cancer Datta 2016 Meta-Analysis     627 Hyperthermia and Radiation Therapy in Locoregional Recurrent Breast Cancers: A Systematic Review and Meta-analysis IJRO icon 48 article
Head and Neck Cancer Datta 2016 Meta-Analysis      451 Hyperthermia and radiotherapy in the management of head and neck cancers: A systematic review and meta-analysis  IJH icon 48 article
Cervical Cancer Datta 2016 Meta-Analysis     807 Hyperthermia and radiotherapy with or without chemotherapy in locally advanced cervical cancer: a systematic review with conventional and network meta-analyses IJH icon 48 article
Summary Review Cihoric 2015 Clinical Review       Hyperthermia-related clinical trials on cancer treatment within the ClinicalTrials.gov registry  IJH icon 48 article
Head & neck Huilgol 2012 Regional HT - Capacitive RT RT+LHT 56 Hyperthermia with radiation in the treatment of locally advanced head and neck cancer: a report of a randomized trial J Cancer Res Ther. icon 48 article
Bladder Cancer Colombo 2010 Intracavitary microwave Intravesical MMC+EHT 75 Long-term outcomes of a randomized controlled trial comparing thermochemotherapy with mitomycin-C alone as adjuvant treatment for non-muscle-invasive bladder cancer (NMIBC)  BJUI icon 48 article
Cervical Cancer Lutgens 2010 Regional HTRTRT+HT Meta     Combined use of hyperthermia and radiation therapy for treating locally advanced cervical carcinoma  CDSR icon 48 article
Melanoma Overgaard 2009 Superficial microwave RT RT+LHT 184 Hyperthermia as an adjuvant to radiation therapy of recurrent or metastatic malignant melanoma. A multicentre randomized trial by the European Society for Hyperthermic Oncology  IJH icon 48 article
Cervical Cancer Franckena 2008 Regional HT - BSD-2000 RT RT+HT 114 Long-term improvement in treatment outcome after radiotherapy and hyperthermia in locoregionally advanced cervix cancer: an update of the Dutch Deep Hyperthermia Trial   IJRO icon 48 article
Cervix, review Harima 2009 Various approaches       Hyperthermia classic commentary: 'A randomized clinical trial of radiation therapy versus thermoradiotherapy in stage IIIB cervical carcinoma IJH  icon 48 article
Rectal Cancer Verwaal 2008 HIPEC intracavity surgery CTX HIPEC 105 8-Year Follow-up of Randomized Trial: Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy Versus Systemic Chemotherapy in Patients with Peritoneal Carcinomatosis of Colorectal Cancer Ann Surg Oncol icon 48 article
Sarcoma limb Cornett 2006 Limb perfusion M+HLP Mplus +HLP 124 Randomized Multicenter Trial of Hyperthermic Isolated Limb Perfusion With Melphalan Alone Compared With Melphalan Plus Tumor Necrosis Factor J Clin Oncol icon 48 article
Breast Jones 2005 Superficial microwave RT RT+LHT 109 Randomized trial of hyperthermia and radiation for superficial tumors J Clin Oncol  icon 48 article
Intraperitoneal Verwaal 2003 HIPEC Ovarian surgical CTX HIPEC 105 Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer J Clin Oncol  icon 48 article
Cervical Cancer Harima 2001 Regional HT RT RT+HT 40 A randomized clinical trial of radiation therapy versus thermoradiotherapy in stage IIIB cervical carcinoma  IJH icon 48 article  
Cervical Cancer Van der Zee  2000 Regional HT - BSD-2000 RT RT+HT 114 Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumors: a prospective, randomized, multicentre trial. Dutch Deep Hyperthermia Group Lancet icon 48 article
Bladder Cancer Van der Zee 2000 Regional HT - BSD-2000 MMC+RT RT+HT 101 Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumors: a prospective, randomized, multicentre trial. Dutch Deep Hyperthermia Group  Lancet icon 48 article
Rectal Cancer Van der Zee 2000 Regional HT - BSD-2000 RT RT+HT 143 Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumors: a prospective, randomized, multicentre trial. Dutch Deep Hyperthermia Group Lancet icon 48 article
Glioblastoma Sneed 1998 Microwave interstitial RT, IRT RT,IRT+IHT 79 Survival benefit of hyperthermia in a prospective randomized trial of brachytherapy boost +/- hyperthermia for glioblastoma multiforme  IJRO icon 48 article
Breast Vernon 1996, 2000 Superficial microwave RT RT+LHT 307 Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: results from five randomized controlled trials. International Collaborative Hyperthermia Group. IJRO  icon 48 article
Esophageal Kitamura 1995 Endocavitary HT RCT RCT+EHT 66 Prospective randomized study of hyperthermia combined with chemoradiotherapy for esophageal carcinoma J Surg Oncol icon 48 article
Esophageal Sugimachi 1994 Endocavitary HT CTX CTX-EHT 40 Chemotherapy combined with or without hyperthermia for patients with oesophageal carcinoma: a prospective randomized trial IJH  icon 48 article
Head & neck Valdagni 1994, 1988 Regional HT - BSD-1000 RT RT+LHT 44 Radical radiation alone versus radical radiation plus microwave hyperthermia for N3 (TNM-UICC) neck nodes: a prospective randomized clinical trial. IJRO  icon 48 article
Rectal Cancer Berdov 1990 Endocavitary HT RT RT+HT 115 Thermoradiotherapy of patients with locally advanced carcinoma of the rectum IJH icon 48 article
Head & neck Datta 1990 Regional HT - Capacitive RT RT+LHT 65 Head and neck cancers: results of thermoradiotherapy versus radiotherapy IJH  icon 48 article
Cervical Cancer Sharma 1989 Intracavity Brachyhperthermia RT RT+IHT 50 Local thermo-radiotherapy in carcinoma cervix: improved local control versus increased incidence of distant metastasis AOFOG icon 48 article
Cervical Cancer Datta 1987 Regional HT RT RT+HT 64 Thermoradiotherapy in the management of carcinoma cervix (stage IIIB): A controlled clinical study  Indian Med Gaz icon 48 article

RT-Radiotherapy; HT-Hyperthermia; LHT-Local Hyperthermia; CHT-Chemothyperthermia; CTX-Chemotherapy; MMC-Mitomycin C; EHT; Endocavity Hyperthermia; IHT-Interstitial Hyperthermia; HIPEC-Heated Intraperitoneal Chemotherapy; RCT-RadioChemotherapy; BCG-Bacillus Calmette-Guerin