• MR System

    Image Guided Thermal Therapy

    The BSD-2000 3D/MR employs the next generation of non-invasive thermometry.
    MR images are translated to map and visualize temperature, allowing
    for precision placement of the hyperthermic heating zone.
    Not for sale in the United States.
  • BSD-200 3D/MR Open Applicator

    Increase Workflow with
    easier patient access

    The Sigma Eye/MR applicator's side opening allows for more natural
    patient access. The unit can be removed and stored, allowing
    the MR system to be used for traditional imaging.
    Not for sale in the United States.
  • BSD-2000 3D/MR Dr with Patient

    Temperature Imaging during treatment

    There is no interruption during the hyperthermia/imaging process. The patient remains in the
    MR system during the full course of treatment. A water bolus is used to make connection
    between the RF signal and the patient. Circulated water can be cooled or heated for patient comfort.
    Not for sale in the United States.
    Learn More
  • BSD-2000 3D/MR Operator

    Realtime Heat Zone Steering

    A great benefit of image-guided thermal therapy
    is the ability to validate and electronically steer the heat zone to
    ensure proper treatment placement and target temperature.
    Not for sale in the United States.
    Learn More Data Sheet

Who is Pyrexar Medical

By leveraging the therapeutic power of focused heat, Pyrexar Medical seeks to revolutionize cancer care. We aim to enhance traditional cancer therapies, with clinically proven and effective options.

We are committed to continuing to advance these pioneering solutions, as we strive to redefine the landscape of cancer care for a brighter and healthier future.

Pyrexar Medical Quality Certifications

Clinical Evidence Matters

Randomized clinical trials (RCT’s) have show significant improvement in clinical outcomes when hyperthermia was added to radiotherapy and/or chemotherapy. Experts in clinical hyperthermia held a consensus meeting (Kadota Fund International Forum 2004) about the evidence of the published clinical results of the RCT’s. Level 1 evidence was found for bladder cancer, breast cancer, cervical cancer, cancer of the esophagus, lymph nodes of head and neck tumors, rectum cancer, soft tissue sarcoma, malignant melanoma, glioblastoma multiform, and various superficial cancers.

Hyperthermia Clinical Trials
Hyperthermia chart demonstrating proven clinical results
Cancer Immune Modulaton

Heat Matters

According to the standards set by the Society of Thermal Medicine (STM), European Society for Hyperthermic Oncology (ESHO) and the Asian Society of Hyperthermic Oncology (ASHO), the benefits of hyperthermia are fully realized when the tumor temperature reaches 39-43 degrees Celsius.

Heat is known to kill cancer cells, shrink tumor size, increase radiosensitivity, inhibit DNA repair, oxygenate hypoxic tumors, produce heat shock proteins, and increase disease-free survival.

Show Me the Data

Clinical Study Reveals Increased Longevity

An independent study published in the Journal of the American Medical Association (JAMA) reports on a 10 year patient follow-up to a phase III clinical study on a Soft Tissue Sarcoma Study. In addition to higher CR, the addition of hyperthermia increased the median long-term survival rate from 6.2 to 15.4 years

Read the Study
Infographic of Soft Tissue Sarcoma Study

Tumor Author Year Method No. of Patients Title Journal Abstract Link
Pediatric Sarcomas Seifert 2016 CT+HT 10 Regional hyperthermia combined with chemotherapy in paediatric, adolescent and young adult patients: current and future perspectives Radiat Oncol icon 48 article
Pediatric Germ Cell Wessalowski 2014 HT 44 Regional deep hyperthermia for salvage treatment of children and adolescents with refractory or recurrent non-testicular malignant germ-cell tumours: an open-label, non-randomised, single-institution, phase 2 study. Lancet Oncol icon 48 article
Pediatric Germ Cell Wessalowski 2003 CT+HT 39 An approach for cure: PEI-chemotherapy and regional deep hyperthermia in children and adolescents with unresectable malignant tumors Klin Padiatr icon 48 article
Germ Cell Schneider 2001 CT+HT 22 Treatment of recurrent malignant sacrococcygeal germ cell tumors: analysis of 22 patients registered in the German protocols MAKEI 83/86, 89, and 96. JCO icon 48 article
Pediatric Germ Cell Wessalowski 1998 CT+HT 10 Hyperthermia for the treatment of patients with malignant germ cell tumors: a phase I/II study in ten children and adolescents with recurrent or refractory tumors Cancer icon 48 article
Germ Cell Tumor Wessalowski 1997 CT+HT 9 Treatment results in children and adolescents with loco-regional recurrences of abdominal germ cell tumors (GCTs): a pilot-study with PEI chemotherapy and regional deep hyperthermia (RHT) in comparison to a matched cohort Klin Padiatr icon 48 article

Tumor Author Year Method No. of Patients Title Journal Abstract Link
Ovarian Fotopoulou 2010 CT+HT 36 Regional abdominal hyperthermia combined with systemic chemotherapy for the treatment of patients with ovarian cancer relapse: Results of a pilot study Int J Hyperthermia icon 48 article
Ovarian Jones 2006 CT+HT 41 Intra-peritoneal cisplatin and whole abdomen hyperthermia for relapsed ovarian carcinoma Int J Hyperthermia icon 48 article
Ovarian Secord 2005 CT+HT 30 Phase I/II trial of intravenous Doxil and whole abdomen hyperthermia in patients with refractory ovarian cancer. Int J Hyperthermia icon 48 article
Ovarian Hahn 2004 CT+HT 32 Prospective assessment of quality of life in ovarian cancer patients receiving whole abdomen hyperthermia and liposomal doxorubicin. Int J Hyperthermia icon 48 article

Tumor Author Year Method No. of Patients Title Journal Abstract Link
Pancreatic Rogers 2021 CRT+HT 9 The addition of deep hyperthermia to gemcitabine-based chemoradiation may achieve enhanced survival in unresectable locally advanced adenocarcinoma of the pancreas Clin Transl Radiat Oncol icon 48 article
Pancreatic He 2019 CT+HT 17 Modified-FOLFIRINOX combined with deep regional hyperthermia in pancreatic cancer: a retrospective study in Chinese patients Int J Hyperthermia icon 48 article
Pancreatic Tschoep-Lechner 2013 CT+HT 23 Gemcitabine and cisplatin combined with regional hyperthermia as second-line treatment in patients with gemcitabine-refractory advanced pancreatic cancer. Int J Hyperthermia icon 48 article
Pancreatic  Maluta 2011  RCT+HT  68 Regional hyperthermia combined with chemoradiotherapy in primary or recurrent locally advanced pancreatic cancer: an open-label comparative cohort trial Strahlenther Onkol icon 48 article 

Tumor Author Year Method No. of Patients Title Journal Abstract Link
Rectal Ott 2021 CRT+HT 111 Neoadjuvant Chemoradiation Combined with Regional Hyperthermia in Locally Advanced or Recurrent Rectal Cancer Cancers icon 48 article
Rectal Gani 2021 RCT+HT 78 Deep regional hyperthermia with preoperative radiochemotherapy in locally advanced rectal cancer, a prospective phase II trial Radiother Oncol icon 48 article
Anal Ott 2018 CRT+HT 112 Chemoradiotherapy with and without deep regional hyperthermia for squamous cell carcinoma of the anus Strahlenther Onkol icon 48 article
Rectal Zwirner 2017 RCT+HT 86 External validation of a rectal cancer outcome prediction model with a cohort of patients treated with preoperative radiochemotherapy and deep regional hyperthermia Int J Hyperthermia icon 48 article
Rectal Gani 2016 HT 103 Long-term local control and survival after preoperative radiochemotherapy in combination with deep regional hyperthermia in locally advanced rectal cancer Int J Hyperthermia icon 48 article
Rectal Schroeder 2012 RCT vs.
RCT+HT		 106 Pathological complete response and sphincter-sparing surgery after neoadjuvant radiochemotherapy with regional hyperthermia for locally advanced rectal cancer compared with radiochemotherapy alone. Int J Hyperthermia icon 48 article
Rectal Maluta 2010 RCT+HT 76 Regional hyperthermia added to intensified preoperative chemo-radiation in locally advanced adenocarcinoma of middle and lower rectum Int J Hyperthermia icon 48 article
Rectal Milani 2008 RCT+RHT 24 Radiochemotherapy in combination with regional hyperthermia in preirradiated patients with recurrent rectal cancer Strahlenther Onkol icon 48 article
Rectal Hildebrandt 2004 RT+HT 9 Regional pelvic hyperthermia as an adjunct to chemotherapy (oxaliplatin, folinic acid, 5-fluorouracil) in pre-irradiated patients with locally recurrent rectal cancer: a pilot study. Int J Hyperthermia icon 48 article
Rectal Juffermans 2003 RT+HT 54 Reirradiation and hyperthermia in rectal carcinoma: a retrospective study on palliative effect. Cancer icon 48 article
Rectal Schaffer 2003 RCT+HT 14 Feasibility and Morbidity of Combined Hyperthermia and Radiochemotherapy in Recurrent Rectal Cancer – Preliminary Results Onkologie icon 48 article
Rectal Romano 2003 RT+HT 57 Pre-operative radio-chemotherapy plus regional hyperthermia in the treatment of advanced rectal cancer: experience with radiation dose escalation IJRO icon 48 article
Rectal Anscher 2000 CT+HT 15 A pilot study of preoperative continuous infusion 5-fluorouracil, external microwave hyperthermia, and external beam radiotherapy for treatment of locally advanced, unresectable, or recurrent rectal cancer. IJRO icon 48 article
Rectal Rau 2000 RCT+HT 54 Preoperative radiochemotherapy in locally advanced or recurrent rectal cancer: regional radiofrequency hyperthermia correlates with clinical parameters. IJRO icon 48 article
Rectal Van der Zee 2000 RT vs.
RT+HT		 143 Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumors: a prospective, randomized, multicentre trial. Dutch Deep Hyperthermia Group Lancet icon 48 article
Tumor Rau 1998 RCT+HT 37 Preoperative Hyperthermia Combined with Radiochemotherapy in Locally Advanced Rectal Cancer - A Phase 11 Clinical Trial Ann Surg icon 48 article

Page 3 of 3

Benefits of Hyperthermia in Cancer Treatment*

Effects Tumor Cell

In the delicate micro-environment of a cancer cell, heat can lead to direct cell death, shrinking tumor size for easier surgical resection.

Low Toxicity

Very low to no toxicity is often reported when administering hyperthermia. There is no known toxicity build-up from multiple treatments.

Increase Blood Flow

Increased blood flow and perfusion at the tumor site promote oxygenation, increasing radiosensitivity.

Survival Benefit

A phase III clinical study shows an increased survival benefit when hyperthermia was added to traditional therapies.

Inhibits DNA Repair

Hyperthermia, in combination with Radiotherapy, will inhibit the DNA repair cycle of radiation-damaged cancer cells.

Heat Shock Proteins

Tumor cells express heat shock proteins when exposed to hyperthermic temperatures allowing tumor-specific antigens to reach the immune system.

Our Products

BSD 500 Superficial and Interstitial Hyperthermia Cancer Treatment System

BSD-500 Superficial/Interstitial

The BSD-500 Superficial/Interstitial Hyperthermia system is a versatile, fully self-contained treatment device in a mobile configuration for maximum treatment flexibility of superficial tumors within 4cm of the skin surface or used interstitially as an adjunct to brachytherapy
BSD-500
Learn More
BSD 2000 Deep Regional Hyperthermia Cancer Treatment System

BSD-2000 Deep Regional

The BSD-2000 Deep Regional Hyperthermia System provides focused RF hyperthermia (heating) at any depth of the body using four-channel - 8 dipoles phased array antennas. 3 Applicator Options • Electronic Steering
BSD-2000
Learn More
BSD 2000 3D Deep Regional Hyperthermia Cancer Treatment System

BSD-2000 3D Deep Regional

The BSD-2000 3D Deep Regional Hyperthermia System provides focused RF hyperthermia (heating) at any depth of the body using 12 channel - 24 dipoles phased array antennas. 2 Applicator Options • Electronic Steering
BSD-2000
Learn More
BSD 2000 3D MR Guided Deep Regional Hyperthermia Cancer Treatment System

BSD-2000 3D/MR Deep Regional

The BSD-2000 3DMR Deep Regional Hyperthermia System provides focused RF hyperthermia (heating) at any depth of the body using 12 channel - 24 dipoles phased array antennas. 2 Applicator Options • Electronic Steering • Image-Guided Thermal Therapy.
BSD-2000 3D/MR
Learn More

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