| Tumor | Author | Year | Method | No. of Patients | Title | Journal | Abstract Link |
| Rectal Cancer | Ott | 2021 | CRT+HT | 111 | Neoadjuvant Chemoradiation Combined with Regional Hyperthermia in Locally Advanced or Recurrent Rectal Cancer | Cancers |  |
| Prostate Cancer | Beck | 2021 | RT+HT | 52 | Salvage-Radiation Therapy and Regional Hyperthermia for Biochemically Recurrent Prostate Cancer after Radical Prostatectomy | Cancers | |
| Rectal Cancer | Gani | 2021 | RCT+HT | 78 | Deep regional hyperthermia with preoperative radiochemotherapy in locally advanced rectal cancer, a prospective phase II trial | Radiother Oncol | |
| Breast Cancer | Stoetzer | 2020 | CT+HT | 53 | Post-Neoadjuvant Gemcitabine and Cisplatin with Regional Hyperthermia for Patients with Triple-Negative Breast Cancer and Non-pCR after Neoadjuvant Chemotherapy: A Single-Institute Experience | Karger | |
| MIBC Bladder Cancer | Merten | 2019 | RCT+HT | 369 | Long‐Term Experience of Chemoradiotherapy Combined with Deep Regional Hyperthermia for Organ Preservation in High‐Risk Bladder Cancer (Ta, Tis, T1, T2) | The Oncologist | |
| Breast Cancer | De-Colle | 2019 | RT+HT | 20 | Hyperthermic chest wall re-irradiation in recurrent breast cancer: a prospective observational study | Strahlenther Onkol | |
| Anal Cancer | Ott | 2018 | CRT+HT | 112 | Chemoradiotherapy with and without deep regional hyperthermia for squamous cell carcinoma of the anus | Strahlenther Onkol | |
| Soft Tissue Sarcoma | Issels | 2018 | CT vs. CT+HT |
341 | Effect of Neoadjuvant Chemotherapy Plus Regional Hyperthermia on Long-term Outcomes Among Patients With Localized High-Risk Soft Tissue Sarcoma: The EORTC 62961-ESHO 95 Randomized Clinical Trial. | JAMA | |
| Rectal Cancer | Zwirner | 2018 | RCT+HT | 86 | External validation of a rectal cancer outcome prediction model with a cohort of patients treated with preoperative radiochemotherapy and deep regional hyperthermia | IJH | |
| Soft Tissue Sarcoma | Angele | 2014 | CT vs. CT+HT |
341 | Effectiveness of regional hyperthermia with chemotherapy for high-risk retroperitoneal and abdominal soft-tissue sarcoma after complete surgical resection: a subgroup analysis of a randomized phase-III multicenter study. | Ann Surg Oncol | |
| Pancreatic Cancer | Tschoep-Lechner | 2013 | CT+HT | 23 | Gemcitabine and cisplatin combined with regional hyperthermia as second-line treatment in patients with gemcitabine-refractory advanced pancreatic cancer. | IJH | |
| Cervical Cancer | Westermann | 2012 | RT+HT | 68 | Long-term survival data of triple modality treatment of stage IIB-III-IVA cervical cancer with the combination of radiotherapy, chemotherapy and hyperthermia - an update. | IJH | |
| Rectal Cancer | Schroeder | 2012 | RCT vs. RCT+HT |
106 | Pathological complete response and sphincter-sparing surgery after neoadjuvant radiochemotherapy with regional hyperthermia for locally advanced rectal cancer compared with radiochemotherapy alone. | IJH | |
| Cervical Cancer | Heijkoop | 2012 | RCT+HT | 43 | Neoadjuvant chemotherapy followed by radiotherapy and concurrent hyperthermia in patients with advanced-stage cervical cancer: a retrospective study | IJH | |
| Pancreatic Cancer | Maluta | 2011 | RCT+HT | 68 | Regional hyperthermia combined with chemoradiotherapy in primary or recurrent locally advanced pancreatic cancer : an open-label comparative cohort trial | Strahlenther Onkol | |
| Ovarian Cancer | Fotopoulou | 2010 | CT+HT | 36 | Regional abdominal hyperthermia combined with systemic chemotherapy for the treatment of patients with ovarian cancer relapse: Results of a pilot study | IJH | |
| Soft Tissue Sarcoma | Issels | 2010 | CT vs. CT+HT |
341 | Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study. | Lancet | |
| Rectal Cancer | Maluta | 2010 | RCT+HT | 76 | Regional hyperthermia added to intensified preoperative chemo-radiation in locally advanced adenocarcinoma of middle and lower rectum | IJH | |
| Soft Tissue Sarcoma | Schlemmer | 2010 | RCT+HT | 47 | Thermochemotherapy in patients with extremity high-risk soft tissue sarcomas (HR-STS) | IJH | |
| Bladder Cancer | Wittlinger | 2009 | RCT+HT | 45 | Quadrimodal treatment of high-risk T1 and T2 bladder cancer: transurethral tumor resection followed by concurrent radiochemotherapy and regional deep hyperthermia | Radiother Oncol | |
| Cervical Cancer | Franckena | 2009 | RT vs. RT+HT |
378 | Radiotherapy and hyperthermia for treatment of primary locally advanced cervix cancer: results in 378 patients | IJRO | |
| Rectal Cancer | Milani | 2008 | RCT+RHT | 24 | Radiochemotherapy in combination with regional hyperthermia in preirradiated patients with recurrent rectal cancer | Strahlenther Onkol | |
| Cervical Cancer | Franckena | 2008 | RT vs. RT+HT |
114 | Long-term improvement in treatment outcome after radiotherapy and hyperthermia in locoregionally advanced cervix cancer: an update of the Dutch Deep Hyperthermia Trial. | IJRO | |
| Prostate Cancer | Maluta | 2007 | CRT+HT | 144 | Conformal radiotherapy plus local hyperthermia in patients affected by locally advanced high risk prostate cancer: preliminary results of a prospective phase II study | IJH | |
| Vaginal Cancer | Aktas | 2007 | RT+HT | 44 | Concomitant radiotherapy and hyperthermia for primary carcinoma of the vagina: a cohort study. | Eur J Obstet | |
| Cervical Cancer | Sreenivasa | 2006 | RCT+HT | 32 | Radiochemotherapy combined with regional pelvic hyperthermia induces high response and resectability rates in patients with nonresectable cervical cancer > or =FIGO IIB "bulky". | IJRO | |
| Ovarian Cancer | Jones | 2006 | CT+HT | 41 | Intra-peritoneal cisplatin and whole abdomen hyperthermia for relapsed ovarian carcinoma | IJH | |
| Cervical Cancer | Westermann | 2005 | RCT+HT | 68 | First results of triple-modality treatment combining radiotherapy, chemotherapy, and hyperthermia for the treatment of patients with stage IIB, III, and IVA cervical carcinoma. | Cancer | |
| Ovarian Cancer | Hahn | 2005 | CT+HT | 32 | Prospective assessment of quality of life in ovarian cancer patients receiving whole abdomen hyperthermia and liposomal doxorubicin. | IJH | |
| Ovarian Cancer | Alvarez Secord | 2005 | CT+HT | 30 | Phase I/II trial of intravenous Doxil and whole abdomen hyperthermia in patients with refractory ovarian cancer. | IJH | |
| Prostrate Cancer | Tilly | 2005 | RT+HT | 22 | Regional hyperthermia in conjunction with definitive radiotherapy against recurrent or locally advanced prostate cancer T3 pN0 M0. | Strahlenther Onkol | |
| Technical Study | Gellermann | 2005 | MRI Imaging | Methods and potentials of magnetic resonance imaging for monitoring radiofrequency hyperthermia in a hybrid system | IJH | |
|
| Rectal Cancer | Hildebrandt | 2004 | RT+HT | 9 | Regional pelvic hyperthermia as an adjunct to chemotherapy (oxaliplatin, folinic acid, 5-fluorouracil) in pre-irradiated patients with locally recurrent rectal cancer: a pilot study. | IJH | |
| Soft Tissue Sarcoma | Fiegl | 2004 | CT+HT | 20 | Ifosfamide, carboplatin and etoposide (ICE) as second-line regimen alone and in combination with regional hyperthermia is active in chemo-pre-treated advanced soft tissue sarcoma of adults. | IJH | |
| Rectal Cancer | Juffermans | 2003 | RT+HT | 54 | Reirradiation and hyperthermia in rectal carcinoma: a retrospective study on palliative effect. | Cancer | |
| Cervical Cancer | Jones | 2003 | RT+HT | 12 | A pilot Phase II trial of concurrent radiotherapy, chemotherapy, and hyperthermia for locally advanced cervical carcinoma. | Cancer | |
| Prostate Cancer | Kalapurakal | 2003 | RT+HT | 13 | Efficacy of irradiation and external hyperthermia in locally advanced, hormone-refractory or radiation recurrent prostate cancer: a preliminary report. | IJRO | |
| Cervical Cancer | Van der Zee | 2003 | RT vs. RT+HT |
114 | The Dutch Deep Hyperthermia Trial: results in cervical cancer | IJH | |
| Rectal Cancer | Romano | 2003 | RT+HT | 57 | Pre-operative radio-chemotherapy plus regional hyperthermia in the treatment of advanced rectal cancer: experience with radiation dose escalation | IJRO | |
| Pediatric Tumors | Wesslowski | 2003 | CT+HT | 39 | An approach for cure: PEI-chemotherapy and regional deep hyperthermia in children and adolescents with unresectable malignant tumors | Klin Padiatr | |
| Soft Tissue Sarcoma | Wendtner | 2002 | CT+HT | 58 | Response to neoadjuvant chemotherapy combined with regional hyperthermia predicts long-term survival for adult patients with retroperitoneal and visceral high-risk soft tissue sarcomas. | JCO | |
| Soft Tissue Sarcoma | Issels | 2001 | CT+HT | 59 | Neoadjuvant chemotherapy combined with regional hyperthermia (RHT) for locally advanced primary or recurrent high-risk adult soft-tissue sarcomas (STS) of adults: long-term results of a phase II study. | Eur J Cancer | |
| Germ Cell Tumors | Schneider | 2001 | CT+HT | 22 | Treatment of recurrent malignant sacrococcygeal germ cell tumors: analysis of 22 patients registered in the German protocols MAKEI 83/86, 89, and 96. | JCO | |
| Soft Tissue Sarcoma | Wendtner | 2001 | RCT+HT | 54 | Treatment of primary, recurrent or inadequately resected high-risk soft-tissue sarcomas (STS) of adults: results of a phase II pilot study (RHT-95) of neoadjuvant chemotherapy combined with regional hyperthermia. | Eur J Cancer | |
| Technical Study | Maguire | 2001 | Thermal Dose | A phase II trial testing the thermal dose parameter CEM43 degrees T90 as a predictor of response in soft tissue sarcomas treated with pre-operative thermoradiotherapy | IJH | |
|
| Prostate Cancer | Kalapurakal | 2001 | RT+HT | 3 | Re-irradiation and external hyperthermia in locally advanced, radiation recurrent, hormone refractory prostate cancer: a preliminary report. | Br J Radiol | |
| Technical Study | Tilly | 2001 | Specific Absorbtion Rate | Temperature data and specific absorption rates in pelvic tumours: predictive factors and correlations. | IJH | |
|
| Rectal Cancer | Anscher | 2000 | CT+HT | 15 | A pilot study of preoperative continuous infusion 5-fluorouracil, external microwave hyperthermia, and external beam radiotherapy for treatment of locally advanced, unresectable, or recurrent rectal cancer. | IJRO | |
| Cervical Cancer | Van der Zee | 2000 | RT vs. RT+HT |
114 | Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumors: a prospective, randomized, multicentre trial. Dutch Deep Hyperthermia Group | Lancet | |
| Rectal Cancer | Rau | 2000 | RCT+HT | 54 | Preoperative radiochemotherapy in locally advanced or recurrent rectal cancer: regional radiofrequency hyperthermia correlates with clinical parameters. | IJRO | |
| Bladder Cancer | Van der Zee | 2000 | MMC+RT vs. RT+HT |
101 | Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumors: a prospective, randomized, multicentre trial. Dutch Deep Hyperthermia Group | Lancet | |
| Rectal Cancer | Van der Zee | 2000 | RT vs. RT+HT |
143 | Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumors: a prospective, randomized, multicentre trial. Dutch Deep Hyperthermia Group | Lancet | |
| Soft Tissue Sarcoma | Prosnitz | 1999 | RT+HT | 97 | The treatment of high-grade soft tissue sarcomas with preoperative thermoradiotherapy. | IJRO | |
| Cervical Cancer | de Wit | 1999 | CT+HT | 19 | A phase I/II study of combined weekly systemic cisplatin and locoregional hyperthermia in patients with previously irradiated recurrent carcinoma of the uterine cervix. | Br J Radiol | |
| Germ Cell Tumor | Wessalowski | 1998 | CT+HT | 7 | Hyperthermia for the treatment of patients with malignant germ cell tumors: a phase I/II study in ten children and adolescents with recurrent or refractory tumors | Cancer | |
| Rectal Cancer | Rau | 1998 | RCT+HT | 37 | Preoperative hyperthermia combined with radiochemotherapy in locally advanced rectal cancer: a phase II clinical trial. | Ann Surg Oncol | |
| Germ Cell Tumor | Wessalowski | 1997 | CT+HT | 9 | Treatment results in children and adolescents with loco-regional recurrences of abdominal germ cell tumors (GCTs): a pilot-study with PEI chemotherapy and regional deep hyperthermia (RHT) in comparison to a matched cohort | Klin Padiatr | |
| Prostate | Anscher | 1997 | RT+HT | 30 | Combined external beam irradiation and external regional hyperthermia for locally advanced adenocarcinoma of the prostate. | IJRO | |
| Deep Tumors | Myerson | 1996 | RT+HT | 66 | A phase I/II study to evaluate radiation therapy and hyperthermia for deep-seated tumours: a report of RTOG 89-08. | IJH | |
| Soft Tissue Sarcoma | Scully | 1994 | RT+HT | 40 | Clinical outcome after neoadjuvant thermoradiotherapy in high grade soft tissue sarcomas | J Surg Oncol | |
| Head & Neck Cancer | Valdagni | 1994 | RT vs. RT+LHT |
44 | Radical radiation alone versus radical radiation plus microwave hyperthermia for N3 (TNM-UICC) neck nodes: a prospective randomized clinical trial. | IJRO | |
| Technical Study | Feldmann | 1993 | Temperature | Deep regional hyperthermia: comparison between the annular phased array and the sigma-60 applicator in the same patients. | IJRO | |
|
| Prostate | Kaplan | 1991 | RT+HT | 6 | Secondary external-beam radiotherapy and hyperthermia for local recurrence after 125-iodine implantation in adenocarcinoma of the prostate | IJRO | |
| Genitourinary Cancer | 1991 | RT vs. RT+HT |
53 | Regional hyperthermia in patients with recurrent genitourinary cancer. | Am J Clin Oncol | |
|
| Technical Study | Myerson | 1991 | Phantom | Phantom studies and preliminary clinical experience with the BSD 2000 | IJH | |
|
| Soft Tissue Sarcoma | Issels | 1990 | CT+HT | 40 | Ifosfamide plus etoposide combined with regional hyperthermia in patients with locally advanced sarcomas: a phase II study. | JCO | |
RT-Radiotherapy; HT-Hyperthermia; LHT-Local Hyperthermia; CHT-Chemothyperthermia; CTX-Chemotherapy; MMC-Mitomycin C; EHT; Endocavity Hyperthermia; IHT-Interstitial Hyperthermia; HIPEC-Heated Intraperitoneal Chemotherapy; RCT-RadioChemotherapy; BCG-Bacillus Calmette-Guerin; CRT-Conformal Radiotherapy